Fungal Metabolite, Epoxyquinol B, Crosslinks Proteins by Epoxy-thiol Conjugation

Gold Solid Surface Thiol Oligo Conjugation

B-Staged Epoxy

A typical epoxy assembly process is to blend the two parts (resin and hardener), deposit the liquid on a substrate, attach a second part, and immediately cure with time and / or heat. But in many cases it may be beneficial to separate the blending / depositing process from the curing process. This could be driven by in-plant logistics, or the need to run each process in separate facilities with...

Thiol proteins in chromatin.

Total half-cystine residues in proteins of pig liver chromatin have been measured. About half of them are present in the reduced state. Thiol groups of non-histone chromatin proteins, which amount to about 40 nmol/mg of protein, are preferentially located in chromatin fragments which are more easily solubilised either by DNAse I or by DNAse II. The data obtained are compatible with an involveme...

Recent Advances in the Anionic Photocurable Epoxy/Thiol-Ene Systems

to several advantages including superior mechanical properties, chemical and heat resistance, low shrinkage, high adhesivity and low toxicity [1]. However, one of the main drawbacks is the inherent fragility due to the high level of crosslinking in these materials. Because of this aspect, several methods to improve their toughness have been reported [2,3]. Our research group focused on improvin...

Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR.

Angiogenesis is the development of new blood vessels to provide oxygen and nutrients and is indispensable for solid tumor growth. Therefore, the inhibition of angiogenesis is an important modality for cancer chemotherapy. Here we report the antiangiogenic mechanism and antitumor effects of epoxyquinol B (EPQB), which was isolated from fungal metabolites. Short-term treatment of EPQB resulted in...